Exodontia associated bacteremia in horses characterized by next generation sequencing

Abstract Bacteremia resulting from dental surgery is increasingly recognized as a health risk, especially in older and immunocompromised patients. Dentistry-associated bacteremia can lead to remote infections, exemplified by valvular endocarditis. Emerging evidence points novel role played oral cavity commensals the pathogenesis of diabetes, respiratory disease, cardiovascular adverse pregnancy outcomes. Whether extraction, commonly undertaken procedure old horses, causes has not been reported extensively. In prospective clinical study using next generation sequencing (based on bacterial 16S rRNA), circulating blood microbiome was characterized before at 1 h following extraction incisor, canine or cheek teeth 29 adult horses with disease. rRNA gene results were compared those gingival swab samples obtained prior location diseased tooth. associated translocated demonstrated undergoing exodontia was, some cases, still evident one hour post-operatively.